Project Description:
This project focused on building an electrochemical biosensor to measure levels of calcitonin gene-related peptide (CGRP) in the blood to help monitor headaches for migraine patients. The sensor uses a specially coated electrode that can recognize and bind to CGRP. When CGRP attaches, a redox reaction occurs that changes the flow of electrons at the electrode, creating an electrical signal. The strength of this signal is related to how much CGRP is present, and it can be measured using simple electrochemical methods. Because CGRP levels tend to increase during migraine attacks, this sensor makes it possible to track changes over time. This information can then be used to better understand a patient’s migraine patterns and adjust treatments, helping create more personalized and effective medicine plans. It also benefits patients directly by helping them better predict when headaches may occur, allowing them to take action earlier and reduce the overall burden of the disease.
